Interleukin (il)-12 is one of the key cytokines in immune regulation and is overexpressed in psoriasis the aim of this study was to update the meta-analysis for the association between il-12 p40 gene (il-12b) rs3212227 polymorphism and risk of psoriasismethodswe performed a literature search from inception to december 2014. The inflammatory disease-associated variants in il12b and il23r encode proteins that are members of the il-12 lack of association of rs3212227 with ra and. F1000prime recommended article: a large-scale genetic association study confirms il12b and leads to the identification of il23r as psoriasis-risk genes. Genetic variations in cytokines and cytokine receptors - download as pdf file (pdf), text file (txt) or read online. The subunit of il-23 (il12b) and its receptor (il23r) gene single-nucleotide polymorphisms (snps) have been shown to be associated with several autoimmune diseases such as inflammatory bowel disease, psoriasis and ankylosing spondylitis.
Journal of investigative dermatology very recently an association of psoriasis variants in genes at chromosomes 1p31 and 5q33 coding for il-23 receptor and its ligand il-12β (= il-12. Il-12 p40, which is encoded by il-12b gene, is known as a component of the bioactive cytokines il-12 and il-23 28 in this meta-analysis, the results indicated that carriers of genotype cc or allele c of il-12b rs3212227 had a lower risk of psoriasis. In this study, we determined whether there is an association of snp rs3212227 with the susceptibility of developing plaque psoriasis and with serum levels of il-12 and il-23 in mestizo population in western mexico.
Bility loci for psoriasis , and the variation of il‐12 is associated with psoriasis in diferent populations [47-49] meta analyses have shown that il‐12b variation (rs3212227, rs6887695. Both il12b markers showed highly significant association with psoriasis in the case-control (rs3212227, odds ratio our results confirm an association between genes in the il-12 / il-23. Between-study heterogeneity was not found during meta-analyses of the association between the il-23 r and il-12b polymorphisms and psoriasis susceptibility generally, publication bias causes a disproportionate number of positive studies, and poses a problem for meta-analyses. The second study as well as the combined data confirmed the significant association of rs3212227/il-12b with bd (cc genotype: combined p c = 63×10 −7 , or = 18. Il-12 immunomodulation delays the onset of lethal peritoneal disease of ovarian cancer 26375522 the il-12b rs3212227 ac and ac+cc genotypes are associated with rheumatoid arthritis risk in older patients,rheumatoid factor positive patients and anti-cyclic peptide antibodies negative patients.
Likewise, effective management of psoriasis is linked to suppression of il-17 signaling (28,29), and genetic findings from genome-wide association studies have implicated genes that are more strongly involved in il-23/il-17 signaling than those for il-12 (5,30. We tested the association between two polymorphisms of il-12(1188ac rs3212227) and il-6 (-174 cg) and the risk of bladder cancer in 261 patients and 251 healthy. Original paper association of il-12b gene rs6887695 polymorphism with hereditary susceptibility and clinical characterization of psoriasis vulgaris in the chinese han population.
Objective recent reports have confirmed association of single-nucleotide polymorphisms (snps) mapping to the interleukin-23 receptor (il-23r) and il-12 genes with psoriasis susceptibility the aim of this study was to determine whether these variants are also associated with susceptibility to. No significant association between the il7ra c/t (rs6897932) and il12b a1188c (rs3212227) gene polymorphisms and ms susceptibility was observed regarding il-12b a1188c (rs3212227), a significant association between the cc genotype and ms progression, expressed as msss, was demonstrated in the female ms group. That il-23 might be more important in the pathogenesis of psoriasis than il-12 (rs3212227), confirming the results of a small japanese study region that. In psoriasis an association with three variants of the il-13 gene was observed : rs1800925, rs20541, and rs848 (this cytokine, such as il-4 and il-10, is secreted by th2 lymphocytes and seems to be important in the innate and adaptive immune response dysregulation that leads to psoriasis.
The results of the present study suggested that the il-12b rs3212227 t and rs3213094 c snps confer an increased risk for psoriasis however, the two il-23 snps that were analyzed, including il-23r rs7530511 and il-23a rs2066808, did not. Resequencing of the il12b gene in psoriasis patients with the rs6887695 of rs3212227 on il-12 expression was of association between rs3212227 and ps, because. Background psoriasis is a common chronic inflammatory skin disease with a strong genetic basis cytokines such as tumor necrosis factor alpha (tnf-α), interleukins (ils) such are il-12 and il-23, and interferon gamma (ifn-γ) are released from various inflammatory and resident cells, and have been implicated in the initiation/maintenance of inflammation. Association of psoriasis and psoriatic arthritis with the association of sle and and il-12/il-23 in psoriasis j immunol 177: 4917-4926 [crossref].